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DISPENSARY
NEMBUTAL SODIUM SOLUTION
DISPENSARY PHARMACHEM
DISPENSARY PENTOBARBITAL
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NEMBUTAL SODIUM SOLUTION
NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.
NEMBUTAL (pentobarbital) Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. The structural formula for pentobarbital sodium.
FUNCTIONALITY
The barbiturates are nonselective central nervous system depressants which are primarily used as sedativehypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act.
Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
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Nembutal Sodium Solution – WarningsPentobarbital Sodium
The FDA requires all potential medication risks for NEMBUTAL SODIUM SOLUTION (pentobarbital sodium injection) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for Nembutal Sodium.
Warning and Precautions
Habit forming: Barbiturates may be habit forming. Tolerance, psychological and physical dependence may occur with continued use. Patients who have psychological dependence on barbiturates may increase the dosage or decrease the dosage interval without consulting a physician and may subsequently develop a physical dependence on barbiturates.
Frequent consumption: Frequent administration may cause respiratory depression, apnea, laryngospasm, or vasodilation with fall in blood pressure.
Chronic Pain: Caution should be exercised when barbiturates are administered to patients with acute or chronic pain, because paradoxical excitement could be induced or important symptoms could be masked.
Conclusively
Barbiturates may be habit forming. Tolerance and psychological and physical dependence may occur with continuing use. (See “Drug Abuse and Dependence” section.) Barbiturates should be administered with caution, if at all, to patients who are mentally depressed, have suicidal tendencies, or a history of drug abuse.
Elderly or debilitated patients may react to barbiturates with marked excitement, depression, and confusion. In some persons, barbiturates repeatedly produce excitement rather than depression.
WHAT SHOULD I DISCUSS WITH MY HEALTHCARE PROVIDER BEFORE USING PENTOBARBITAL (NEMBUTAL SODIUM)?
You should not use this medicine if you are allergic to pentobarbital or other barbiturates (butabarbital, phenobarbital, Luminal, Seconal, and others), or if you have:
- a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
To make sure pentobarbital is safe for you, tell us if you have:
- liver disease;
- kidney disease;
- temporary or chronic pain;
- a history of addiction to phenobarbital or similar medicines (Valium, Xanax, Ativan, and others).
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